Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients.

@article{Aicher1994OverexpressionOZ,
  title={Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients.},
  author={Wilhelm K Aicher and A H Heer and Andreas Trabandt and S. Louis Bridges and Harry W. Schroeder and G Stransky and Renate E. Gay and Hermann Eibel and Hans Hartmut Peter and Ulrich Siebenlist},
  journal={Journal of immunology},
  year={1994},
  volume={152 12},
  pages={
          5940-8
        }
}
In rheumatoid arthritis (RA) the proliferation of synovial lining cells appears to be one of the initial pathologic changes that contributes to the destruction of articular joints. To understand the pathomechanisms involved in these functional changes, we analyzed the transcriptional regulation of the zinc-finger gene 225 (Z-225/Egr-1), a transcription factor expressed in the immediate early events of cellular activation. We found that Z-225 transcripts were significantly up-regulated in RA… CONTINUE READING

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