Overexpression of vimentin: role in the invasive phenotype in an androgen-independent model of prostate cancer.

@article{Singh2003OverexpressionOV,
  title={Overexpression of vimentin: role in the invasive phenotype in an androgen-independent model of prostate cancer.},
  author={Sadmeet Singh and Skanda K. Sadacharan and Scott Su and Arie S. Belldegrun and Sujata Persad and Gurmit Singh},
  journal={Cancer research},
  year={2003},
  volume={63 9},
  pages={2306-11}
}
The androgen-sensitive LNCaP prostate cancer cell line is less invasive than hormone-insensitive lines. CL1, an aggressive, hormone-insensitive LNCaP subline derived by continuous passaging in hormone-depleted medium, was compared with the parental cell line by cDNA microarray analysis. The gene coding for the intermediate filament protein vimentin was found to be highly up-regulated in the CL1 subline. This difference was confirmed by Northern and Western blots and visualized by… CONTINUE READING

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