Overexpression of type 1 angiotensin II receptors impairs excitation-contraction coupling in the mouse heart.

@article{Rivard2011OverexpressionOT,
  title={Overexpression of type 1 angiotensin II receptors impairs excitation-contraction coupling in the mouse heart.},
  author={Katy Rivard and Scott A. Grandy and Annie Douillette and Pierre Paradis and Mona Nemer and Bruce G. Allen and C{\'e}line Fiset},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={301 5},
  pages={
          H2018-27
        }
}
  • K. Rivard, S. Grandy, +4 authors C. Fiset
  • Published 19 August 2011
  • Biology
  • American journal of physiology. Heart and circulatory physiology
Transgenic mice that overexpress human type 1 angiotensin II receptor (AT(1)R) in the heart develop cardiac hypertrophy. Previously, we have shown that in 6-mo AT(1)R mice, which exhibit significant cardiac remodeling, fractional shortening is decreased. However, it is not clear whether altered contractility is attributable to AT(1)R overexpression or is secondary to cardiac hypertrophy/remodeling. Thus the present study characterized the effects of AT(1)R overexpression on ventricular L-type… 
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