Overexpression of tumor necrosis factor-alpha diminishes pulmonary fibrosis induced by bleomycin or transforming growth factor-beta.

@article{Fujita2003OverexpressionOT,
  title={Overexpression of tumor necrosis factor-alpha diminishes pulmonary fibrosis induced by bleomycin or transforming growth factor-beta.},
  author={Masaki J. Fujita and John M. Shannon and Osamu Morikawa and Jack Gauldie and Nobuyuki Hara and Robert J. Mason},
  journal={American journal of respiratory cell and molecular biology},
  year={2003},
  volume={29 6},
  pages={669-76}
}
Tumor necrosis factor-alpha (TNF-alpha) is thought to be important in the development of pulmonary fibrosis. However, surfactant protein-C/TNF-alpha transgenic mice do not spontaneously develop pulmonary fibrosis but instead develop alveolar enlargement and loss of elastic recoil. We hypothesized that overexpression of TNF-alpha in the lung requires an additional insult to produce fibrosis. In this study we evaluated whether TNF-alpha overexpression altered the development of pulmonary fibrosis… CONTINUE READING
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