Overexpression of tumor necrosis factor alpha by a recombinant rabies virus attenuates replication in neurons and prevents lethal infection in mice.

@article{Faber2005OverexpressionOT,
  title={Overexpression of tumor necrosis factor alpha by a recombinant rabies virus attenuates replication in neurons and prevents lethal infection in mice.},
  author={Milosz Faber and Michael Bette and Mirjam A. R. Preuss and Rojjanaporn Pulmanausahakul and Jennifer Rehnelt and Matthias J Schnell and Bernhard Dietzschold and Eberhard Weihe},
  journal={Journal of virology},
  year={2005},
  volume={79 24},
  pages={15405-16}
}
The effect of tumor necrosis factor alpha (TNF-alpha) on rabies virus (RV) infection of the mouse central nervous system (CNS) was studied, using recombinant RV engineered to express either soluble TNF-alpha [SPBN-TNF-alpha+] or insoluble membrane-bound TNF-alpha [SPBN-TNF-alpha(MEM)]. Growth curves derived from infections of mouse neuroblastoma NA cells revealed significantly less spread and production of SPBN-TNF-alpha+ than of SPBN-TNF-alpha(MEM) or SPBN-TNF-alpha-, which carries an… CONTINUE READING

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