Overexpression of transketolase TKTL1 is associated with shorter survival in laryngeal squamous cell carcinomas

@article{Voelker2007OverexpressionOT,
  title={Overexpression of transketolase TKTL1 is associated with shorter survival in laryngeal squamous cell carcinomas},
  author={Hans-Ullrich Voelker and Matthias Scheich and Bernd Schmausser and Ulrike K{\"a}mmerer and Matthias Eck},
  journal={European Archives of Oto-Rhino-Laryngology},
  year={2007},
  volume={264},
  pages={1431-1436}
}
Tumorigenesis involves energy production by aerobic glycolysis (“Warburg effect”) in malignant tumors. One of the key enzymes is transketolase. Transketolase, transketolase-like-1 (TKTL1), and transketolase-like-2 are known. Antibodies against TKTL1 exist for immunohistochemical investigations. This study investigated the influence of TKTL1 on survival and metastasizing in 40 laryngeal squamous cell carcinomas (SCCs, T2–T4, 27 metastasized). Staining was assessed by an immunoreactive score (IRS… CONTINUE READING

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