Corpus ID: 32515241

Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.

@article{Garcia1990OverexpressionOT,
  title={Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.},
  author={Maur{\'i}cio S. Garcia and Danielle Derocq and Pascal Pujol and Henri Rochefort},
  journal={Oncogene},
  year={1990},
  volume={5 12},
  pages={
          1809-14
        }
}
  • Maurício S. Garcia, Danielle Derocq, +1 author Henri Rochefort
  • Published in Oncogene 1990
  • Biology, Medicine
  • Cathepsin D, an aspartic lysosomal proteinase, is overexpressed by breast cancer cells and highly correlated with the occurrence of metastasis in patients. We used an adenovirus transformed rat cell line that does not secrete cathepsin D, to study the consequences of transfecting human cathepsin D cDNA. Overexpression of human cathepsin D in stable transfectant clones, results in higher initial growth rates in low serum conditions, overgrowth at high cell densities resulting in stellate… CONTINUE READING

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