Overexpression of tissue inhibitor of matrix metalloproteinase-1 inhibits vascular smooth muscle cell functions in vitro and in vivo.

@article{Forough1996OverexpressionOT,
  title={Overexpression of tissue inhibitor of matrix metalloproteinase-1 inhibits vascular smooth muscle cell functions in vitro and in vivo.},
  author={Reza Forough and Noriyuki Koyama and David Hasenstab and H J Lea and M. M. Clowes and Seppo T Nikkari and Alexander W. Clowes},
  journal={Circulation research},
  year={1996},
  volume={79 4},
  pages={812-20}
}
Arterial smooth muscle cells (SMCs) are in a quiescent growth state under normal physiological conditions, but they can be stimulated to proliferate and migrate from one tissue compartment to another if the vessel is injured. This response might require a selective and focal increase in tissue degradation, which might be mediated through the increased production of matrix metalloproteinases (MMPs). Blockade of MMP activity might therefore inhibit the SMC response to injury. To test this… CONTINUE READING