Overexpression of the wild type p73 gene in human bladder cancer

@article{Yokomizo1999OverexpressionOT,
  title={Overexpression of the wild type p73 gene in human bladder cancer},
  author={Akira Yokomizo and Ming Mai and Donald J. Tindall and Liang Cheng and David G. Bostwick and Seiji Naito and David I. Smith and Wanguo Liu},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={1629-1633}
}
p73, a first p53 relative, was recently identified and shown to be monoallelically expressed in a number of different human tissues. To determine the potential role of this gene in human bladder cancer, we investigated p73 expression levels, allelic expression patterns, and analysed p73 mutations in 23 unselected primary invasive bladder cancers with matched normal tissues and in seven bladder cancer cell lines. In a comparison between normal and tumor tissues using quantitative RT – PCR… CONTINUE READING
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