Overexpression of the thymosin β-4 gene is associated with malignant progression of SW480 colon cancer cells

@article{Wang2003OverexpressionOT,
  title={Overexpression of the thymosin β-4 gene is associated with malignant progression of SW480 colon cancer cells},
  author={W. S.-Y. Wang and Po-min Chen and Hung-Liang Hsiao and Sy-Yeuan Ju and Yeu Su},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={3297-3306}
}
Thymosin β-4 (Tβ-4), a small peptide originally isolated from calf thymus, modulates the formation of F-actin microfilaments by sequestering the monomeric G-actin. Recent studies have shown that overexpression of the Tβ-4 gene occurs not only in many human carcinomas but also in the highly metastatic melanomas and fibrosarcomas. However, little is known about the specific growth advantages acquired by different tumors from this genetic abnormality. To address the above questions, Tβ-4… CONTINUE READING