Overexpression of the shortest isoform of histone demethylase LSD1 primes hematopoietic stem cells for malignant transformation.

@article{Wada2015OverexpressionOT,
  title={Overexpression of the shortest isoform of histone demethylase LSD1 primes hematopoietic stem cells for malignant transformation.},
  author={Taeko Wada and D. Koyama and Jiro Kikuchi and Hiroaki Honda and Yusuke Furukawa},
  journal={Blood},
  year={2015},
  volume={125 24},
  pages={3731-46}
}
Recent investigations indicate that epigenetic regulators act at the initial step of myeloid leukemogenesis by forming preleukemic hematopoietic stem cells (HSCs), which possess the increased self-renewal potential but retain multidifferentiation ability, and synergize with genetic abnormalities in later stages to develop full-blown acute myeloid leukemias. However, it is still unknown whether this theory is applicable to other malignancies. In this study, we demonstrate that lysine-specific… CONTINUE READING