Overexpression of the prolyl isomerase PIN1 promotes cell growth in osteosarcoma cells.

@article{Zhou2013OverexpressionOT,
  title={Overexpression of the prolyl isomerase PIN1 promotes cell growth in osteosarcoma cells.},
  author={Lu Zhou and Byung-Hyun Park and Jong Hyuk Park and Kyu Yun Jang and Ho-Sung Park and Sajeev Wagle and Kwang Bok Lee and Jung Ryul Kim},
  journal={Oncology reports},
  year={2013},
  volume={29 1},
  pages={
          193-8
        }
}
PIN1 was recently identified as a peptidyl-prolyl cis-trans isomerase (PPIase). It binds to and isomerizes specific pSer/Thr-Pro motifs and catalytically induces conformational changes after phosphorylation. PIN1 plays an important role in several cellular events, such as cell cycle progression, transcriptional regulation, RNA processing, cell proliferation and differentiation. The relationship between PIN1 and osteosarcoma has not… 
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Development of Pin1 inhibitors and their potential as therapeutic agents.
TLDR
The possible applications of Pin1 inhibitors to a variety of diseases including malignant tumors are discussed, and the recent advances in Pin1 inhibitor research, which have been reported are introduced.
Role of PIN1 on in vivo periodontal tissue and in vitro cells
TLDR
This study is the first to demonstrate that PIN1 is expressed in developing periodontal tissue, and in vitro PDLCs and cementoblasts, and thus may play an important role inperiodontal regeneration.
Critical role of XBP1 in cancer signalling is regulated by PIN1.
TLDR
It is shown that PIN1 prolyl isomerase interacts with the active form of XBP1 (XBP1s) in a phosphorylation-dependent manner and promotes XBP 1s-induced cell proliferation and transformation through the regulation of X BP1 stability.
Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics
TLDR
The roles of PIN1 in cancer and PIN1-targeted small-molecule compounds are discussed and the structure and function of these phosphorylated proteins regulated by PIN1 are closely related to cancer development.
The overexpression of BAMBI and its involvement in the growth and invasion of human osteosarcoma cells.
TLDR
The results suggest that BAMBI plays a key role in the pathogenesis and progression of osteosarcoma by regulating the expression of β-catenin and other signaling molecules via the pathways involved in the regulation of the cell cycle.
Polydatin promotes apoptosis through upregulation the ratio of Bax/Bcl-2 and inhibits proliferation by attenuating the β-catenin signaling in human osteosarcoma cells.
TLDR
It is shown that polydatin dose-dependently inhibited proliferation and promoted apoptosis in 143B and MG63 osteosarcoma cells, examined by MTT assay and Annexin V-FITC apoptosis detection, and indicated that PD could inhibit the proliferation by inhibiting the β-catenin signaling and induce apoptosis via upregulation the ratio of Bax/Bcl-2 in human ostea cells.
Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway
The expression of Hic-5 was detected in osteosarcoma patients and osteosarcoma cell lines by RT-PCR. Then RFP-sh-Hic-5 was transfected into osteosarcoma cell lines. The effect of Hic-5 on cell…
MiR-378 promotes the cell proliferation of osteosarcoma through down-regulating the expression of Kruppel-like factor 9.
TLDR
It is shown that miR-378 was highly expressed in human OS tissues and cell lines and the molecular interaction between mi R-378 and KLF9 was demonstrated, indicating the therapeutic potential of miR -378 for OS.
PIN1 Inhibition Suppresses Osteoclast Differentiation and Inflammatory Responses
TLDR
This study is the first to demonstrate that PIN1 inhibition exhibits anti-inflammatory effects and blocks osteoclastic differentiation in LPS- and nicotine-treated PDLCs.
High expression levels of Cyr61 and VEGF are associated with poor prognosis in osteosarcoma.
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TLDR
The results suggest that Pin1‐mediated postphosphorylation regulation may provide a unique opportunity for disrupting oncogenic pathways, and thereby represent an appealing target for novel anticancer therapies.
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TLDR
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TLDR
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