Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

  title={Overexpression of the obese (ob) gene in adipose tissue of human obese subjects},
  author={Fredrik L{\"o}nnqvist and Peter Arner and Louise Nordfors and Martin Schalling},
  journal={Nature Medicine},
Obesity is accompanied by complications such as hypertension, non–insulin–dependent diabetes mellitus and atherosclerosis, which in turn cause ischaemic heart disease, stroke and premature death1–3. The underlying mechanisms behind imbalance in energy intake and energy expenditure that lead to obesity are still controversial. In most populations, obesity is more common among women than men and is a multifactorial phenotype, which may result from a complex network of genetic and nongenetic… CONTINUE READING


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