Overexpression of the anaphylatoxin receptors, complement anaphylatoxin 3a receptor and complement anaphylatoxin 5a receptor, in the nasal mucosa of patients with mild and severe persistent allergic rhinitis.

@article{Jun2008OverexpressionOT,
  title={Overexpression of the anaphylatoxin receptors, complement anaphylatoxin 3a receptor and complement anaphylatoxin 5a receptor, in the nasal mucosa of patients with mild and severe persistent allergic rhinitis.},
  author={Sung Whan Jun and Tae Hoon Kim and Heung M. Lee and Seung Hoon Lee and Woo Joo Kim and Se Jin Park and Yang Soo Kim and Sang Hag Lee},
  journal={The Journal of allergy and clinical immunology},
  year={2008},
  volume={122 1},
  pages={119-25}
}
BACKGROUND Although the complement anaphylatoxin peptides, complement anaphylatoxin 3a (C3a) and complement anaphylatoxin 5a (C5a), are implicated in the inflammatory process in allergic rhinitis, a direct interaction between allergic mucosa and complement receptors has not been demonstrated. OBJECTIVE We investigated the expressional levels and distributional patterns of the C3a receptor (C3aR) and C5a receptor (C5aR) in normal, mild, and severe persistent allergic nasal mucosa. METHODS… CONTINUE READING