Overexpression of the amplified Pip4k2β gene from 17q11–12 in breast cancer cells confers proliferation advantage

@article{Luoh2004OverexpressionOT,
  title={Overexpression of the amplified Pip4k2β gene from 17q11–12 in breast cancer cells confers proliferation advantage},
  author={S Luoh and Natarajan Venkatesan and Reshimi Tripathi},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={1354-1363}
}
Gene amplification is common in solid tumors and is associated with adverse prognosis, disease progression, and development of drug resistance. A small segment from chromosome 17q11–12 containing the HER-2/Neu gene is amplified in about 25% of breast cancer. HER-2/Neu amplification is associated with adverse prognosis and may predict response to chemotherapy and hormonal manipulation. Moreover, HER-2/Neu amplification may select patients for anti-HER-2/Neu-based therapy with Herceptin. We and… CONTINUE READING

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