Overexpression of the SK3 channel alters vascular remodeling during pregnancy, leading to fetal demise.

@article{Rada2012OverexpressionOT,
  title={Overexpression of the SK3 channel alters vascular remodeling during pregnancy, leading to fetal demise.},
  author={Cara C. Rada and Stephanie Lynn Pierce and Daniel W. Nuno and Kathy Zimmerman and Kathryn G. Lamping and Noelle C. Bowdler and Robert Monroe Weiss and Sarah K. England},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2012},
  volume={303 7},
  pages={
          E825-31
        }
}
The maternal cardiovascular system undergoes hemodynamic changes during pregnancy via angiogenesis and vasodilation to ensure adequate perfusion of the placenta. Improper vascularization at the maternal-fetal interface can cause pregnancy complications and poor fetal outcomes. Recent evidence indicates that small conductance Ca(2+)-activated K(+) channel subtype 3 (SK3) contributes to vascular remodeling during pregnancy, and we hypothesized that abnormal SK3 channel expression would alter the… CONTINUE READING

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