Overexpression of the Nek2 kinase in colorectal cancer correlates with beta-catenin relocalization and shortened cancer-specific survival.

@article{Neal2014OverexpressionOT,
  title={Overexpression of the Nek2 kinase in colorectal cancer correlates with beta-catenin relocalization and shortened cancer-specific survival.},
  author={Christopher P. Neal and Andrew M Fry and Catherine Moreman and A C S W Mcgregor and Giuseppe S. Garcea and David Paul Berry and Margaret M. Manson},
  journal={Journal of surgical oncology},
  year={2014},
  volume={110 7},
  pages={828-38}
}
The serine/threonine kinase Nek2 (NIMA-related kinase 2) regulates centrosome separation and mitotic progression, with overexpression causing induction of aneuploidy in vitro. Overexpression may also enable tumour progression through effects upon Akt signalling, cell adhesion markers and the Wnt pathway. The objective of this study was to examine Nek2 protein expression in colorectal cancer (CRC). Nek2 protein expression was examined in a panel of CRC cell lines using Western blotting and… CONTINUE READING
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Up‐regulation of NEK2 by microRNA‐128 methylation is associated with poor prognosis in colorectal cancer

  • Y Takahashi, T Iwaya, G Sawada
  • Ann Surg Oncol 2014;21:205–212
  • 2014
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