Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function.

@article{Demirov2002OverexpressionOT,
  title={Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function.},
  author={Dimiter G Demirov and Akira Ono and Jan Marc Orenstein and Eric O. Freed},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 2},
  pages={955-60}
}
Efficient budding of HIV-1 from the plasma membrane of infected cells requires the function of a 6-kDa protein known as p6. A highly conserved Pro-Thr-Ala-Pro (PTAP) motif (the "late" or "L" domain), is critical for the virus-budding activity of p6. Recently, it was demonstrated that the product of tumor susceptibility gene 101 (TSG101), which contains at its N terminus a domain highly related to ubiquitin-conjugating (E2) enzymes, binds HIV-1 Gag in a p6-dependent fashion. We examined the… CONTINUE READING
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