Overexpression of the FoxO1 Ameliorates Mesangial Cell Dysfunction in Male Diabetic Rats.

@article{Qin2015OverexpressionOT,
  title={Overexpression of the FoxO1 Ameliorates Mesangial Cell Dysfunction in Male Diabetic Rats.},
  author={Guijun Qin and Yingni Zhou and Feng Guo and Lei Ren and Lina Wu and Yuanyuan Zhang and Xiaojun Ma and Qingzhu Wang},
  journal={Molecular endocrinology},
  year={2015},
  volume={29 7},
  pages={1080-91}
}
The dysfunction of mesangial cells (MCs) in high-glucose (HG) conditions plays pivotal role in inducing glomerular sclerosis by causing the imbalance between generation and degradation of extracellular matrix (ECM) proteins, which ultimately leads to diabetic nephropathy. This study was designed to determine the function of forkhead box protein O1 (FoxO1), an important transcription factors in regulating cell metabolism and oxidative stress, in MCs in HG conditions. Up-regulation of fibronectin… CONTINUE READING