Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas.

@article{Watanabe1996OverexpressionOT,
  title={Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas.},
  author={Kunihiko Watanabe and Osamu Tachibana and Keiko Sata and Yasuhiro Yonekawa and Paul Kleihues and Hiroko Ohgaki},
  journal={Brain pathology},
  year={1996},
  volume={6 3},
  pages={217-23; discussion 23-4}
}
Glioblastoma multiforme, the most malignant human brain tumor, may develop de novo (primary glioblastoma) or through progression from low-grade or anaplastic astrocytoma (secondary glioblastoma). We present further evidence that primary and secondary glioblastomas constitute distinct disease entities which develop through the acquisition of different genetic alterations. We analyzed p53 mutations, p53 protein accumulation and epidermal growth factor receptor (EGFR) overexpression in 49 biopsies… CONTINUE READING
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