Overexpression of the E2F-1 transcription factor gene mediates cell transformation.

@article{Yang1995OverexpressionOT,
  title={Overexpression of the E2F-1 transcription factor gene mediates cell transformation.},
  author={Xiu Hua Yang and Todd L. Sladek},
  journal={Gene expression},
  year={1995},
  volume={4 4-5},
  pages={
          195-204
        }
}
The E2F transcription factor can regulate expression of numerous cellular genes controlling proliferation, including proto-oncogenes and genes regulating cell cycle progression. Therefore, genes comprising the E2F gene family could potentially contribute to carcinogenesis. To test the potential of E2F to act as a transforming gene, a cDNA encoding E2F-1 was constitutively overexpressed in established rodent cells using a retroviral vector. Overexpressed E2F-1 was functional, as shown by… CONTINUE READING

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