Overexpression of the CD155 gene in human colorectal carcinoma.

  title={Overexpression of the CD155 gene in human colorectal carcinoma.},
  author={David Masson and Anne Charlotte Jarry and B{\'e}atrice Baury and Philippe Blanchardie and Christian L. Laboisse and Patrick Lustenberger and Marc G Denis},
  volume={49 2},
BACKGROUND AND AIMS The Tage4 gene (tumour associated glycoprotein E4) is overexpressed in rat colon tumours and Min mouse intestinal adenomas. The rat Tage4 protein has approximately 40% identity with human CD155, a member of the immunoglobulin superfamily coding for a transmembrane protein capable of serving as an entry receptor for poliovirus, porcine pseudorabies virus, and bovine herpesvirus 1. Analysis of the rat Tage4 gene has revealed structural and functional similarities with the… CONTINUE READING