Overexpression of the A1 adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance.

@article{Dong2001OverexpressionOT,
  title={Overexpression of the A1 adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance.},
  author={Qing Dong and Henry N. Ginsberg and Bernard F. Erlanger},
  journal={Diabetes, obesity & metabolism},
  year={2001},
  volume={3 5},
  pages={360-6}
}
In-vitro studies have implicated the A(1) adenosine receptor (A(1)AR) of adipocytes in inhibition of lipolysis, stimulation of lipogenesis and enhancement of the action of insulin on glucose metabolism. To determine whether any of these activities were physiologically relevant in an intact animal, A(1)AR was overexpressed in adipose tissue of transgenic… CONTINUE READING