Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension.

@article{Maclean2004OverexpressionOT,
  title={Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension.},
  author={Margaret R. Maclean and Graeme A. Deuchar and Martin N. Hicks and Ian Morecroft and Sanbing Shen and John Sheward and Janet F Colston and Lynn Loughlin and Margaret Nilsen and Yvonne Dempsie and Anthony J. Harmar},
  journal={Circulation},
  year={2004},
  volume={109 17},
  pages={2150-5}
}
BACKGROUND Increased serotonin (5-hydroxytryptamine, 5-HT) transporter activity has been observed in human familial pulmonary hypertension. METHODS AND RESULTS We investigated pulmonary hemodynamics and the development of hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling in mice overexpressing the gene for the 5-HT transporter (5-HTT+ mice). Right ventricular pressure was elevated 3-fold in normoxic 5-HTT+ mice compared with their wild-type controls. Hypoxia-induced… CONTINUE READING

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