Overexpression of the β subunit of human chorionic gonadotropin promotes the transformation of human ovarian epithelial cells and ovarian tumorigenesis.

@article{Guo2011OverexpressionOT,
  title={Overexpression of the β subunit of human chorionic gonadotropin promotes the transformation of human ovarian epithelial cells and ovarian tumorigenesis.},
  author={Xiaoqing Guo and Guangzhi Liu and Isaiah Gregory Schauer and Gong Yang and I Mercado-uribe and Fan Yang and Shiwu Zhang and Yuanli He and Jinsong Liu},
  journal={The American journal of pathology},
  year={2011},
  volume={179 3},
  pages={1385-93}
}
Ovarian carcinoma is the most lethal gynecologic malignancy, however underlying molecular events remain elusive. Expression of human chorionic gonadotropin β subunit (β-hCG) is clinically significant for both trophoblastic and nontrophoblastic cancers; however, whether β-hCG facilitates ovarian epithelial cell tumorigenic potential remains uncharacterized. Immortalized nontumorigenic ovarian epithelial T29 and T80 cells stably overexpressing β-hCG were examined for alterations in cell cycle and… CONTINUE READING
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Ovarian cancer

  • KR Cho, M Shih Ie
  • Annu Rev Pathol
  • 2009

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