Overexpression of survivin is correlated with increased invasion and metastasis of colorectal cancer.

@article{Chu2012OverexpressionOS,
  title={Overexpression of survivin is correlated with increased invasion and metastasis of colorectal cancer.},
  author={Xiaoyuan Chu and Long-bang Chen and Jing-Hua Wang and Quan-Sheng Su and J R Yang and Yong Lin and Li-Jun Xue and Xiao-Bei Liu and Xiao-Bei Mo},
  journal={Journal of surgical oncology},
  year={2012},
  volume={105 6},
  pages={520-8}
}
BACKGROUND The aim of this study was to investigate the association of survivin expression with metastasis of colorectal cancer (CRC). METHODS RT-PCR and Western blot assays were performed to detect survivin expression in CRC cells and normal intestinal epithelial cell. The expression of survivin gene was also detected in 15 CRC tissues, surrounding and adjacent colon tissues. Moreover, survivin expression in 48 CRC tissues with or without lymph node metastasis was analyzed. Multivariate… CONTINUE READING