Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells.

  title={Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells.},
  author={Kiyoko Yoshioka and Shigeru Nakamori and Kyogo Itoh},
  journal={Cancer research},
  volume={59 8},
Adhesion of tumor cells to host cell layers and subsequent migration are pivotal steps in cancer invasion and metastasis. The small GTP-binding protein RhoA controls cell adhesion and motility through organization of the actin cytoskeleton and regulation of actomyosin contractility. Cultured rat MM1 hepatoma cells migrate through a mesothelial cell monolayer in vitro in a serum-dependent, RhoA-mediated manner (K. Yoshioka et al., J. Biol. Chem., 273: 5146-5154, 1998). Furthermore, the ROCK… CONTINUE READING
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