Overexpression of serum response factor in astrocytes improves neuronal plasticity in a model of early alcohol exposure.

@article{Paul2012OverexpressionOS,
  title={Overexpression of serum response factor in astrocytes improves neuronal plasticity in a model of early alcohol exposure.},
  author={A Pelckmans Paul and Alexandre E Medina},
  journal={Neuroscience},
  year={2012},
  volume={221},
  pages={193-202}
}
Neuronal plasticity deficits underlie many of the cognitive problems seen in fetal alcohol spectrum disorders (FASD). We have developed a ferret model showing that early alcohol exposure leads to a persistent disruption in ocular dominance (OD) plasticity. Recently, we showed that this deficit could be reversed by overexpression of serum response factor (SRF) in the primary visual cortex during the period of monocular deprivation (MD). Surprisingly, this restoration was observed throughout the… CONTINUE READING
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