Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice.

@article{Ohashi2006OverexpressionOR,
  title={Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice.},
  author={Shinya Ohashi and Akiyoshi Nishio and H. Richard Nakamura and Masanori Asada and Hiroyuki Tamaki and Kimio Kawasaki and Toshiro Fukui and Junji Yodoi and Tsutomu Chiba},
  journal={Antioxidants & redox signaling},
  year={2006},
  volume={8 9-10},
  pages={1835-45}
}
Chronic pancreatitis (CP) is considered to result from repetitive pancreatic injury, and sustained production of various proinflammatory cytokines and chemokines are closely involved in its pathogenesis. Monocyte chemoattractant protein 1 (MCP-1), a member of the CC chemokine family, is believed to contribute to the progression of CP through monocyte/macrophage recruitment. This study aimed to clarify the protective role of thioredoxin-1 (TRX-1), a redox-regulating protein with antioxidative… CONTINUE READING

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