Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.

@article{Sharif1999OverexpressionOP,
  title={Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.},
  author={T R Sharif and M H Sharif},
  journal={International journal of oncology},
  year={1999},
  volume={15 2},
  pages={237-43}
}
Prognosis for astroglial brain tumors that are not amenable to surgical resection remains poor. Consequently, a need to identify new cellular targets and chemotherapeutics for the treatment of astroglial tumors remains. Important reports indicate that human astroglial cell lines express higher protein kinase C (PKC) activity in comparison to normal astrocytes. PKC designates a family of kinases that regulate many cellular functions including cell growth and differentiation. The tight regulation… CONTINUE READING

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