Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma.

@article{Feng2016OverexpressionOP,
  title={Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma.},
  author={Xiaodong Feng and Yuchen Jiang and Liang Xie and Lu Jiang and Jing Li and Chongkui Sun and Hao Xu and Ruinan Wang and Min Zhou and Yu Zhou and Hongxia Dan and Zhiyong Wang and Ning Ji and Peng Deng and Ga Liao and Ning Geng and Yun Xiang Wang and Dunfang Zhang and Yunfeng Lin and L Ye and Xinhua Liang and Longjiang Li and Gang Luo and Mingye Feng and Juan Fang and Xin Zeng and Zhi Wang and Qianming Chen},
  journal={Journal of experimental & clinical cancer research : CR},
  year={2016},
  volume={35},
  pages={35}
}
BACKGROUND Despite recent advances in oral squamous cell carcinoma (OSCC) diagnosis and therapy, disease recurrence remains common and is strongly associated with mortality. It is therefore critical to identify new targets for both treatment and diagnostic purposes. We aimed at investigating the role of PA28α, a proteasomal activator in OSCC. METHODS The expression of PA28α was examined in a panel of OSCC cell lines and tissues, associated with oncomine analysis. In a large OSCC patient… CONTINUE READING