Overexpression of programmed death ligand 1 in dendritic cells inhibits allogeneic lymphocyte activation in mice.

@article{Li2012OverexpressionOP,
  title={Overexpression of programmed death ligand 1 in dendritic cells inhibits allogeneic lymphocyte activation in mice.},
  author={Wen-Zhi Li and Xiang Wang and Renfu Chen and Haitao Steve Zhu and Gang Chen and Xiaoqing Sun},
  journal={The Journal of surgical research},
  year={2012},
  volume={176 2},
  pages={e79-87}
}
BACKGROUND Co-stimulatory molecules are pivotal for T cell activation. It is increasingly recognized that programmed death ligand 1 (PD-L1) is a novel co-stimulatory molecule, which raises the question as to whether PD-L1 regulates T cell responses. This study aimed to investigate the inhibitory effects of PD-L1 on T cell activation. MATERIALS AND METHODS We constructed a transgenic vector containing the complete PD-L1 gene, which interacts with the inhibitory receptor PD-1 in T cell-mediated… CONTINUE READING