Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice.

@article{Zhou2001OverexpressionOP,
  title={Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice.},
  author={Hou Min Zhou and Isabelle Bolon and Alexandra Nichols and Annelise Wohlwend and Jean Dominique Vassalli},
  journal={Cancer research},
  year={2001},
  volume={61 3},
  pages={970-6}
}
The serpin plasminogen activator inhibitor (PAI) type 2 is expressed in differentiated epidermal keratinocytes. To explore its role in this tissue, we studied the impact of PAI-2 overexpression on epidermal differentiation and skin carcinogenesis. A mouse PAI-2-encoding transgene was targeted to basal epidermis and hair follicles under the control of the bovine keratin type 5 gene promoter. Two mouse lines were established, one of which strongly expressed the transgene and produced elevated… CONTINUE READING
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