Overexpression of phosphorylated mammalian target of rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer.

@article{Yu2009OverexpressionOP,
  title={Overexpression of phosphorylated mammalian target of rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer.},
  author={Guanzhen Yu and Jiejun Wang and Ying Chen and Xi Wang and Jun Pan and Gang Li and Zhiliang Jia and Qiang Hua Li and James C. Yao and Keping Xie},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 5},
  pages={1821-9}
}
PURPOSE We determined the expression of mammalian target of rapamycin (mTOR) and its activated form, p-mTOR, in Chinese patients with gastric cancer and its clinical effects and underlying mechanisms. EXPERIMENTAL DESIGN Tissue microarray blocks containing gastric cancer tissue and matched noncancer gastric tissue specimens obtained from 1,072 patients were constructed. Expression of total mTOR and p-mTOR in these specimens was analyzed using immunohistochemical studies and confirmed by… CONTINUE READING

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