Overexpression of phospholemman alters contractility and [Ca(2+)](i) transients in adult rat myocytes.

@article{Song2002OverexpressionOP,
  title={Overexpression of phospholemman alters contractility and [Ca(2+)](i) transients in adult rat myocytes.},
  author={Jianliang Song and Xue-Qian Zhang and Lois L Carl and Anwer Qureshi and Lawrence I. Rothblum and Joseph Y Cheung},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={283 2},
  pages={H576-83}
}
Previous studies showed increased phospholemman (PLM) mRNA after myocardial infarction (MI) in rats (Sehl PD, Tai JTN, Hillan KJ, Brown LA, Goddard A, Yang R, Jin H, and Lowe DG. Circulation 101: 1990-1999, 2000). We tested the hypothesis that, in normal adult rat cardiac myocytes, PLM overexpression alters contractile function and cytosolic Ca(2+) concentration ([Ca(2+)](i)) homeostasis in a manner similar to that observed in post-MI myocytes. Compared with myocytes infected by control… CONTINUE READING