Overexpression of p53 protein correlates with a high risk of malignant transformation of adenomas in patients with multiple colorectal adenomas

  title={Overexpression of p53 protein correlates with a high risk of malignant transformation of adenomas in patients with multiple colorectal adenomas},
  author={Lu-juan Shan and Y. Nakamura and Z Zhang and Xuefeng Jing and M. Nakamura and Maki Murakami and Toyoharu Yokoi and Kennichi Kakudo},
  journal={Pathology International},
To assess the correlation of p53 oncoprotein expression with the high risk of developing carcinomas in patients with multiple colorectal adenomas, 25 cases with histologic carcinoma in adenoma (CIA) were examined by immunohistochemistry using a monoclonal antibody specific to human p53 protein (wild and mutant). The 25 cases were classlfied into multiple and single groups. The former contained 13 cases with synchronous multiple colorectal adenomas (one to six adenomas) and adenocarcinoma. The… 
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    Best practice & research. Clinical gastroenterology
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This chapter outlines the principles underlying the molecular characterization of pre-malignant lesions, taking colorectal neoplasia as the main model.
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p53 expression patterns in colorectal adenomas and early carcinomas: A special reference to depressed adenoma and non‐polypoid carcinoma
The increase of p53 expression fromadenoma to carcinoma supports the hypothesis of an adenoma‐carcinoma sequence in a polypoid tumor and depressed adenomas are thus considered to have a high potential risk of carcinoma.
p53 expression in colorectal adenomas.
It is suggested that immunocytochemical demonstration of p53 protein may be a suitable method for the routine detection of subpopulations of cells which, by clonal expansion, could acquire a growth advantage within an adenoma during the neoplastic process.
Overexpression of p53 protein and histologic grades of dysplasia in colorectal adenomas
Overexpression of p53 protein in adenomas with mild or moderate dysplasia and existence of two types of expression in adanomas with severe Dysplasia suggested the possible existence of different pathways in the adenoma to carcinoma progression.
High frequency of p53 expression in colo-rectal adenomatous polyps.
Immunohistochemical p53-positivity is a common event in colonic adenomas, not dependent on dysplasia degree, and might be the result of p53 wild-type increase, due to the typical genomic instability of colonicAdenomas.
p53 oncoprotein overexpression correlates with mutagen-induced chromosome fragility in head and neck cancer patients with multiple malignancies.
The data suggest that subjects with increased susceptibility to carcingogens after exposure to tobacco or alcohol are at higher risk for multiple cancers in which one of the most common genetic events is aberrant p53 expression.
The correlation between p53 tumor suppressor gene and proliferating cell nuclear antigen expressions in colorectal adenocarcinoma
PCNA is a p53 regulated protein that is needed for DNA repair as well as replication, and it is suggested that there might be a relationship between PCNA and the malignant potential of colorectal carcinomas.
Familial and nutritional risk factors for p53 overexpression in colorectal cancer.
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    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
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The p53 (positive) dependent pathway was characterized by an inverse association with cruciferous vegetables, and p53-independent tumors were characterized by family history and beef consumption, which may indicate the significance of linking epidemiology and molecular biology in assessing specific etiological pathways.
The relationship between smoking exposure and p53 overexpression in colorectal cancer.
An epidemiological study to determine whether p53 protein overexpression, in tumours obtained at the time of resection, is associated with cigarette exposure in colorectal cancer revealed an elevated risk for ex-smokers and current smokers and no dose-response relationship was found for total pack-year smoking.
Genetic alterations in the adenoma–carcinoma sequence
Several different genetic alterations were identified that occur during colorectal tumorigenesis, including the gene dcc, which has significant sequence similarity to neural cell adhesion molecules and other related cell‐surface glycoproteins and may have important functions in mediating cell growth and differentiation.
Mutagen sensitivity in patients with head and neck cancers: a biologic marker for risk of multiple primary malignancies.
Sensitivity to bleomycin-induced chromosomal damage serves as an indicator of genetic susceptibility to multiple primary malignancies in patients with head and neck cancers.