Overexpression of p53 protein correlates with a high risk of malignant transformation of adenomas in patients with multiple colorectal adenomas

@article{Shan1998OverexpressionOP,
  title={Overexpression of p53 protein correlates with a high risk of malignant transformation of adenomas in patients with multiple colorectal adenomas},
  author={Lu-juan Shan and Y. Nakamura and Z Zhang and Xuefeng Jing and M. Nakamura and Maki Murakami and Toyoharu Yokoi and Kennichi Kakudo},
  journal={Pathology International},
  year={1998},
  volume={48}
}
To assess the correlation of p53 oncoprotein expression with the high risk of developing carcinomas in patients with multiple colorectal adenomas, 25 cases with histologic carcinoma in adenoma (CIA) were examined by immunohistochemistry using a monoclonal antibody specific to human p53 protein (wild and mutant). The 25 cases were classlfied into multiple and single groups. The former contained 13 cases with synchronous multiple colorectal adenomas (one to six adenomas) and adenocarcinoma. The… 
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