Overexpression of p53 protein and outcome of patients treated with chemoradiation for carcinoma of the anal canal: a report of randomized trial RTOG 87-04. Radiation Therapy Oncology Group.

@article{Bonin1999OverexpressionOP,
  title={Overexpression of p53 protein and outcome of patients treated with chemoradiation for carcinoma of the anal canal: a report of randomized trial RTOG 87-04. Radiation Therapy Oncology Group.},
  author={Steven Bonin and Thomas F. Pajak and Anthony H. Russell and Lawrence R. Coia and Kristie J. Paris and Marshall S. Flam and Edward R Sauter},
  journal={Cancer},
  year={1999},
  volume={85 6},
  pages={1226-33}
}
BACKGROUND Despite encouraging results with chemoradiation as the primary means of managing carcinoma of the anal canal, approximately 20% of patients will develop a local recurrence. This study examined the prognostic significance of p53 nuclear protein overexpression in the pretreatment biopsies of patients treated with chemoradiation for epidermoid carcinoma of the anal canal. METHODS All patients were treated in a prospective, randomized Radiation Therapy Oncology Group trial (RTOG 87-04… CONTINUE READING

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