Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

@inproceedings{Chi2010OverexpressionOO,
  title={Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice},
  author={Zai-Long Chi and Masakazu Akahori and Minoru Obazawa and Masayoshi Minami and Toru Noda and Naoki Nakaya and Stanislav I. Tomarev and Kazuhide Kawase and Tetsuya Yamamoto and Setsuko Noda and Masaki Sasaoka and Atsushi Shimazaki and Yuichiro Takada and Takeshi Iwata},
  booktitle={Human molecular genetics},
  year={2010}
}
Glaucoma is one of the leading causes of bilateral blindness affecting nearly 8 million people worldwide. Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) and is often associated with elevated intraocular pressure (IOP). However, patients with normal tension glaucoma (NTG), a subtype of primary open-angle glaucoma (POAG), develop the disease without IOP elevation. The molecular pathways leading to the pathology of NTG and POAG are still unclear. Here, we describe… CONTINUE READING
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