Overexpression of nitric oxide synthase by the endothelium attenuates bleomycin-induced lung fibrosis and impairs MMP-9/TIMP-1 balance.

@article{Yoshimura2006OverexpressionON,
  title={Overexpression of nitric oxide synthase by the endothelium attenuates bleomycin-induced lung fibrosis and impairs MMP-9/TIMP-1 balance.},
  author={Sho Yoshimura and Yoshihiro Nishimura and Teruaki Nishiuma and Tomoya Yamashita and Kazuyuki Kobayashi and Mitsuhiro Yokoyama},
  journal={Respirology},
  year={2006},
  volume={11 5},
  pages={546-56}
}
BACKGROUND Nitric oxide (NO) produced by endothelial NO synthase (eNOS) is thought to effect an anti-inflammatory response, but its mechanism is still unknown. METHODS eNOS transgenic (eNOS-TG) mice and their littermate controls (C57/BL6) were used to clarify the role of NO derived from eNOS. Bleomycin hydrochloride (1 U/body/day) or PBS was injected intraperitoneally. RESULTS Subpleural fibrotic changes and hydroxyproline content in the eNOS-TG mice were significantly reduced compared with… CONTINUE READING