Overexpression of netrin-1 induces neovascularization in the adult mouse brain.

  title={Overexpression of netrin-1 induces neovascularization in the adult mouse brain.},
  author={Yongfeng Fan and Fanxia Shen and Yongmei Chen and Qi Hao and Weizhong Liu and Hua Su and William L. Young and Guo-Yuan Yang},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={28 9},
Netrin-1 is a critical molecule for axonal pathfinding during embryo development, and because of its structural homology to the endothelial mitogens, it may share its effects on vascular network formation. Using an adeno-associated viral netrin-1 vector (AAV-NT-1) gene transfer, we demonstrated that netrin-1 was able to stimulate the proliferation and migration of human cerebral endothelial cells (HCECs) and human aortic smooth muscle cells (HASMCs) compared with the control (P<0.05), and could… CONTINUE READING
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