Overexpression of nerve growth factor in transgenic mice induces novel sympathetic projections to primary sensory neurons.

@article{Davis1994OverexpressionON,
  title={Overexpression of nerve growth factor in transgenic mice induces novel sympathetic projections to primary sensory neurons.},
  author={Brian M. Davis and Kathryn M Albers and Kim B. Seroogy and David M. Katz},
  journal={The Journal of comparative neurology},
  year={1994},
  volume={349 3},
  pages={464-74}
}
Peripheral nerve crush induces novel projections from noradrenergic sympathetic neurons to sensory ganglia, and it has been suggested that these projections provide an anatomical substrate for chronic pain syndromes that occur after nerve injury. The present study demonstrates that novel sympathetic projections to sensory neurons are also induced in transgenic mice that overexpress nerve growth factor (NGF) in the skin. Specifically, a large proportion of trigeminal neurons in NGF transgenic… CONTINUE READING