Overexpression of nerve growth factor in skin increases sensory neuron size and modulates Trk receptor expression.

@article{Goodness1997OverexpressionON,
  title={Overexpression of nerve growth factor in skin increases sensory neuron size and modulates Trk receptor expression.},
  author={T P Goodness and Kathryn M Albers and Frank E. Davis and Brian M. Davis},
  journal={The European journal of neuroscience},
  year={1997},
  volume={9 8},
  pages={1574-85}
}
Sensory neuron development and differentiation is dependent on a family of growth factors known as neurotrophins. Neurotrophins modulate neuron development via trk tyrosine kinase receptor proteins trkA, trkB and trkC. To determine how elevated levels of a target-derived neurotrophin might affect neuronal differentiation, we analysed trk expression in the trigeminal ganglion of transgenic mice that overexpressed nerve growth factor (NGF) in the skin. Increased levels of NGF caused a five-fold… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
GangliaNo subtypeNeurons
Neurotrophins modulate neuron development via trk tyrosine kinase receptor proteins trkA , trkB and trkC. To determine how elevated levels of a target - derived neurotrophin might affect neuronal differentiation , we analysed trk expression in the trigeminal ganglion of transgenic mice that overexpressed nerve growth factor ( NGF ) in the skin .
NeuronsNo subtypeGanglia
Neurotrophins modulate neuron development via trk tyrosine kinase receptor proteins trkA , trkB and trkC. To determine how elevated levels of a target - derived neurotrophin might affect neuronal differentiation , we analysed trk expression in the trigeminal ganglion of transgenic mice that overexpressed nerve growth factor ( NGF ) in the skin .
Neurotrophins modulate neuron development via trk tyrosine kinase receptor proteins trkA , trkB and trkC. To determine how elevated levels of a target - derived neurotrophin might affect neuronal differentiation , we analysed trk expression in the trigeminal ganglion of transgenic mice that overexpressed nerve growth factor ( NGF ) in the skin .
Sensory neuron development and differentiation is dependent on a family of growth factors known as neurotrophins .
Neurotrophins modulate neuron development via trk tyrosine kinase receptor proteins trkA , trkB and trkC. To determine how elevated levels of a target - derived neurotrophin might affect neuronal differentiation , we analysed trk expression in the trigeminal ganglion of transgenic mice that overexpressed nerve growth factor ( NGF ) in the skin .
Neurotrophins modulate neuron development via trk tyrosine kinase receptor proteins trkA , trkB and trkC. To determine how elevated levels of a target - derived neurotrophin might affect neuronal differentiation , we analysed trk expression in the trigeminal ganglion of transgenic mice that overexpressed nerve growth factor ( NGF ) in the skin .
Neurotrophins modulate neuron development via trk tyrosine kinase receptor proteins trkA , trkB and trkC. To determine how elevated levels of a target - derived neurotrophin might affect neuronal differentiation , we analysed trk expression in the trigeminal ganglion of transgenic mice that overexpressed nerve growth factor ( NGF ) in the skin .
Neurotrophins modulate neuron development via trk tyrosine kinase receptor proteins trkA , trkB and trkC. To determine how elevated levels of a target - derived neurotrophin might affect neuronal differentiation , we analysed trk expression in the trigeminal ganglion of transgenic mice that overexpressed nerve growth factor ( NGF ) in the skin .
Sensory neuron development and differentiation is dependent on a family of growth factors known as neurotrophins .
Neurotrophins modulate neuron development via trk tyrosine kinase receptor proteins trkA , trkB and trkC. To determine how elevated levels of a target - derived neurotrophin might affect neuronal differentiation , we analysed trk expression in the trigeminal ganglion of transgenic mice that overexpressed nerve growth factor ( NGF ) in the skin .
Neurotrophins modulate neuron development via trk tyrosine kinase receptor proteins trkA , trkB and trkC. To determine how elevated levels of a target - derived neurotrophin might affect neuronal differentiation , we analysed trk expression in the trigeminal ganglion of transgenic mice that overexpressed nerve growth factor ( NGF ) in the skin .
Neurotrophins modulate neuron development via trk tyrosine kinase receptor proteins trkA , trkB and trkC. To determine how elevated levels of a target - derived neurotrophin might affect neuronal differentiation , we analysed trk expression in the trigeminal ganglion of transgenic mice that overexpressed nerve growth factor ( NGF ) in the skin .
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