Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma.

  title={Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma.},
  author={Mariko Tsukagoshi and Satoshi Wada and Takehiko Yokobori and Bolag Altan and Norihiro Ishii and Akira Watanabe and Norio Kubo and Fumiyoshi Saito and Ken-ichiro Araki and Hideki Suzuki and Yasuo Hosouchi and Hiroyuki Kuwano},
  journal={Cancer science},
  volume={107 2},
The natural killer group 2 member D (NKG2D) receptor and its ligands are important mediators of immune responses to tumors. NKG2D ligands are overexpressed in several malignant tumor types; however, the prognostic value of these ligands is unclear. Here, we aimed to elucidate the role of NKG2D ligands in extrahepatic cholangiocarcinoma (EHCC). We therefore investigated the expression of the NKG2D receptor and its ligands MHC class I chain-related proteins A and B (MICA/B), unique long 16… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 5 times. VIEW TWEETS

From This Paper

Topics from this paper.


Publications citing this paper.


Publications referenced by this paper.
Showing 1-10 of 28 references

immunotherapy with antibodies to the PD-1 and PD-L1 pathway

D Cosman, J Mullberg, CL Sutherland
Trends Mol Med • 2015

Molecular bases for the regulation of NKG 2 D ligands in cancer

RW McGilvray, RA Eagle, +3 authors LG Durrant
Front Immunol • 2014

creatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K ⁄Akt signaling pathway

AC Benitez, Z Dai, HH Mann
BMC Cancer • 2014

gand interactions: impairing NKG2D-mediated cytotoxicity and anti-tumor immune surveillance

DH Raulet
Semin Cancer Biol • 2014

regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells

T Bald, J Landsberg, D Lopez-Ramos
Sci Transl Med • 2013

tributes to invasion and metastasis of extrahepatic cholangiocarcinoma, resulting in a poor prognosis

K Araki, T Shimura, H Suzuki
Cancer Sci • 2013

Similar Papers

Loading similar papers…