Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma.

@article{Tsukagoshi2016OverexpressionON,
  title={Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma.},
  author={Mariko Tsukagoshi and Satoshi Wada and Takehiko Yokobori and Bolag Altan and Norihiro Ishii and Akira Watanabe and Norio Kubo and Fumiyoshi Saito and Ken-ichiro Araki and Hideki Suzuki and Yasuo Hosouchi and Hiroyuki Kuwano},
  journal={Cancer science},
  year={2016},
  volume={107 2},
  pages={116-22}
}
The natural killer group 2 member D (NKG2D) receptor and its ligands are important mediators of immune responses to tumors. NKG2D ligands are overexpressed in several malignant tumor types; however, the prognostic value of these ligands is unclear. Here, we aimed to elucidate the role of NKG2D ligands in extrahepatic cholangiocarcinoma (EHCC). We therefore investigated the expression of the NKG2D receptor and its ligands MHC class I chain-related proteins A and B (MICA/B), unique long 16… CONTINUE READING
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