Overexpression of myeloid zinc finger 1 suppresses matrix metalloproteinase-2 expression and reduces invasiveness of SiHa human cervical cancer cells.

@article{Tsai2012OverexpressionOM,
  title={Overexpression of myeloid zinc finger 1 suppresses matrix metalloproteinase-2 expression and reduces invasiveness of SiHa human cervical cancer cells.},
  author={S J Tsai and J. -M. Hwang and Shu-Ching Hsieh and Tsung-Ho Ying and Yi-Hsien Hsieh},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={425 2},
  pages={462-7}
}
Myeloid zinc finger 1 (MZF1) gene belongs to the Kruppel family of zinc finger transcription factors. MZF1 has been suggested to play an important role in the tumorigenesis, invasion, and apoptosis of various tumor cells. However, the role of MZF1 in human cervical cancer remains unclear. To investigate the molecular mechanisms of MZF1 and its functional role in human cervical cancer cell migration and invasion, we experimented on stable SiHa cells overexpressing MZF1. We found that MZF1… CONTINUE READING