Overexpression of mitofilin in the mouse heart promotes cardiac hypertrophy in response to hypertrophic stimuli.

@article{Zhang2014OverexpressionOM,
  title={Overexpression of mitofilin in the mouse heart promotes cardiac hypertrophy in response to hypertrophic stimuli.},
  author={Yuan Zhang and Jing Xu and Yu-Xuan Luo and Xi-Zhou An and Ran Zhang and Guang Mang Liu and Hongliang Li and Hou-zao Chen and De-Pei Liu},
  journal={Antioxidants & redox signaling},
  year={2014},
  volume={21 12},
  pages={1693-707}
}
AIMS Mitofilin was originally described as a heart muscle protein because of its abundance in the heart tissue; however, its function in the heart is still to be elucidated. Thus, this study aims at investigating the role of mitofilin in the heart in response to hypertrophic stimuli. RESULTS In this study, a significant increase in mitofilin expression was observed in the hearts of patients with hypertrophic cardiomyopathy. Transgenic (TG) mice with cardiomyocyte-specific overexpression of… CONTINUE READING
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