Overexpression of miniexon gene decreases virulence of Leishmania major in BALB/c mice in vivo.

@article{Antoniazi2000OverexpressionOM,
  title={Overexpression of miniexon gene decreases virulence of Leishmania major in BALB/c mice in vivo.},
  author={S Antoniazi and Herm{\^e}nio Cavalcante Lima and Angela Kaysel Cruz},
  journal={Molecular and biochemical parasitology},
  year={2000},
  volume={107 1},
  pages={57-69}
}
During the construction of a physical map for Leishmania major (LV39) chromosome 2 we have rescued and characterized a L. major (LV39) derived genomic clone bearing solely as insert a long stretch of the miniexon gene array. The recombinant was devised as a tool to study the effect of miniexon overexpression on virulence and growth advantage. Such clone, 32D05, contains approximately 40 kb of the miniexon tandem array. We have examined the course of infection in susceptible BALB/c mice… CONTINUE READING

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