Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes

@article{Fang2011OverexpressionOM,
  title={Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes},
  author={J. Fang and X. Song and J. Tian and Hu-Yan Chen and D. Li and J. Wang and A. Ren and W. Yuan and L. Lin},
  journal={Apoptosis},
  year={2011},
  volume={17},
  pages={410-423}
}
  • J. Fang, X. Song, +6 authors L. Lin
  • Published 2011
  • Medicine, Biology
  • Apoptosis
  • MicroRNAs (miRNAs) are a novel class of powerful, endogenous regulators of gene expression. In an intact rat model of myocardial ischemia caused by coronary artery ligation, this study identified 17 miRNAs that changed more than 1.5-fold in the myocardium subjected to 4-h ischemia. Using miRNA microarray analysis, most of these aberrantly expressed miRNAs were confirmed by quantitative RT-PCR. MiR-378, a significantly down-regulated miRNA, was selected for further function study. In serum… CONTINUE READING
    MicroRNA-378 Alleviates Cerebral Ischemic Injury by Negatively Regulating Apoptosis Executioner Caspase-3
    • 20
    • Highly Influenced
    • Open Access
    MiR-153 regulates cardiomyocyte apoptosis by targeting Nrf2/HO-1 signaling
    • 7
    • Highly Influenced
    MiR-532-5p alleviates hypoxia-induced cardiomyocyte apoptosis by targeting PDCD4.
    • 15
    Proteome Modulation in H9c2 Cardiac Cells by microRNAs miR-378 and miR-378*
    • 21
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 40 REFERENCES
    MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease
    • 344
    • Open Access
    MicroRNA-133 controls cardiac hypertrophy
    • 1,581