Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes

@article{Fang2011OverexpressionOM,
  title={Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes},
  author={Ji J Fang and Xiao-wei Song and Jianrong Tian and Hu-Yan Chen and Dong-feng Li and Jianfei Wang and An-jing Ren and Wen-jun Yuan and Li Lin},
  journal={Apoptosis},
  year={2011},
  volume={17},
  pages={410-423}
}
MicroRNAs (miRNAs) are a novel class of powerful, endogenous regulators of gene expression. In an intact rat model of myocardial ischemia caused by coronary artery ligation, this study identified 17 miRNAs that changed more than 1.5-fold in the myocardium subjected to 4-h ischemia. Using miRNA microarray analysis, most of these aberrantly expressed miRNAs were confirmed by quantitative RT-PCR. MiR-378, a significantly down-regulated miRNA, was selected for further function study. In serum… CONTINUE READING

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