Overexpression of miR-21 in patients with ulcerative colitis impairs intestinal epithelial barrier function through targeting the Rho GTPase RhoB.

@article{Yang2013OverexpressionOM,
  title={Overexpression of miR-21 in patients with ulcerative colitis impairs intestinal epithelial barrier function through targeting the Rho GTPase RhoB.},
  author={Yongzhi Yang and Yanlei Ma and Chenzhang Shi and Hongqi Chen and Hui-Zhen Zhang and Niwei Chen and Peng Zhang and Feng Wang and Jun Yang and Jianjun Yang and Qingchao Zhu and Yong C Liang and Wen Fang Wu and Renyuan Gao and Zhe Yang and Yang Zou and Huanlong Qin},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={434 4},
  pages={746-52}
}
Although epithelial barrier dysfunction in the gut has been extensively reported in ulcerative colitis (UC), the pathogenesis of this disease is not completely understood. In the present study, we investigated the role of miR-21 in regulating intestinal epithelial barrier function in UC. Colonic biopsies were obtained from 30 chronic UC patients and 30 healthy controls. Using real-time quantitative polymerase chain reaction (qRT-PCR), we found that both the mucosal and serum levels of miR-21… CONTINUE READING