Overexpression of miR-125b, a novel regulator of innate immunity, in eosinophilic chronic rhinosinusitis with nasal polyps.

@article{Zhang2012OverexpressionOM,
  title={Overexpression of miR-125b, a novel regulator of innate immunity, in eosinophilic chronic rhinosinusitis with nasal polyps.},
  author={Xinhao Zhang and Ya-Na Zhang and Huabin Li and Chun-yan Hu and Nan Wang and Ping-Ping Cao and Bo Liao and Xiang Lu and Yong-hua Cui and Zeng Liu},
  journal={American journal of respiratory and critical care medicine},
  year={2012},
  volume={185 2},
  pages={140-51}
}
RATIONALE Eosinophilic chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) represents a hard-to-treat subtype of CRS. OBJECTIVES To determine the pattern of expression and biologic role of microRNAs (miRNAs) in CRS, particularly in eosinophilic CRSwNP. METHODS Global miRNA expression in sinonasal mucosa from controls, CRS without nasal polyps (CRSsNP), and patients with eosinophilic CRSwNP was compared using miRNA microarrays. MiR-125b expression was detected by means of quantitative… CONTINUE READING
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