Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization.

@article{Chen1990OverexpressionOM,
  title={Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization.},
  author={L. C. -M. Chen and John P. O'Bryan and Helene S. Smith and Enbo Liu},
  journal={Oncogene},
  year={1990},
  volume={5 9},
  pages={1391-5}
}
Genetic alterations are involved in the development of human breast cancer. We sought to isolate genes that are differentially expressed or suppressed in cultured human breast carcinoma cells as compared to cultured normal human breast epithelial cells by employing differential screening of selected cDNA libraries. Analysis of several clones thus isolated revealed that the matrix Gla protein (MGP) gene is overexpressed in the breast cancer cell line 600 PEI, though is transcribed at lower… CONTINUE READING

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